3 Overlooked Human Factors That Make-or-Break Mergers and Acquisitions

Organizations that integrate people, culture, and physical space into their M&A strategy can unlock lasting value.

Loffler Companies, St. Louis Park, Minnesota. Photo by Brandon Stengel.

When organizations announce a merger or acquisition, headlines usually focus on the billion-dollar deals, market shares, and technology integration. But beneath the surface, the true test of success often lies in a far less tangible realm: the human equation.

While financial, legal, and technological integration are essential, overlooking the two largest cost centers and value drivers — employees and the environments that support their work — can derail even the most promising mergers.

Key takeaways:

  • Human factors like culture and talent are often overlooked in mergers and acquisitions, yet they are critical to long-term success.
  • Real estate, when treated as a strategic asset, can drive operational efficiency, cultural alignment, and employee engagement during M&A transitions.
  • Workplace design that reflects the merged company’s values and vision can foster unity, productivity, and a shared sense of purpose.

Why Culture and Talent Matter

With mergers and acquisitions, it’s logical to focus on business integration: aligning operations, consolidating resources, and recalibrating business strategies. But attention to the human side of the equation is equally important. It’s the people who are the engine that will drive the new organization forward and determine whether the promised synergies are realized or lost.

Studies show that between 60% and 80% of mergers fail to achieve their intended objectives, with cultural incompatibility cited as a primary reason. When two organizations with different values, leadership styles, and ways of working are asked to work together without thoughtful integration, confusion and friction can undermine both productivity and morale.

Real Estate as a Strategic Lever

Real estate is often dismissed as just a cost center, but it can be a powerful lever for value creation, operational efficiency, and cultural alignment during mergers and acquisitions (M&A).

Here’s how organizations can use real estate strategically in today’s M&A landscape:

  • Identify redundancies and plan consolidations: A thorough review of both companies’ real estate portfolios can highlight overlapping resources and underutilized spaces. Strategic consolidation opportunities not only reduce costs but also streamline operations and align the physical footprint with the new organization’s goals. When managed transparently, this process can accelerate employee integration and give staff a voice in shaping their future work environment.
  • Align the workplace design with the new company’s vision: Thoughtful workplace design — reflecting the merged company’s brand and culture — can foster unity. Integrating flexible workspaces, technology-enabled environments, and amenities that embody shared values encourages new work behaviors and boosts engagement, productivity, and a sense of shared purpose.
  • Elevate real estate to a strategic function: Treat real estate as a dynamic asset that actively supports your merged business objectives. Use data analytics to monitor supply and demand, apply change management processes to communicate shifts, and conduct occupancy evaluations for real-time feedback. Regularly reviewing your real estate assets ensures they continue to deliver a competitive advantage.

In today’s M&A landscape, success demands a holistic approach that reaches beyond financial spreadsheets. Organizations that prioritize culture, talent, and real estate as strategic levers don’t just minimize risk — they unlock the full potential of the merger.

By intentionally addressing the human equation and transforming physical environments to support new ways of working, companies can convert potential friction into lasting synergy and drive long-term value creation.

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Kimberly Zeiser
Kimberly is a design manager and regional financial services leader for Gensler’s North Central region. She has experience leading multiple interior projects for large commercial clients and has become a trusted advisor working with a dynamic list of companies, including Discover Financial Services, Federal Reserve Bank, and Heidrick & Struggles. Kimberly is based in Chicago. Contact her at .
Cindy Coleman
Cindy is a Director of Strategy at Gensler’s Chicago office. Formerly the Editorial Lead of the Gensler Research Institute, she oversaw key publications such as the Global Workplace Survey and Climate Action Survey. With a background in design, writing, and research, Cindy distills complex information into strategic insights. Contact her at .