- 9-Stories, 200,000-Square-Feet
- 100% Electric
- Offset Massing and Dynamic Shifting Volumes
- Interconnecting Stairs Act as a Vertical Ribbon of Circulation
- Three Tenant-Ready Speculative Lab Floors
- Multiple Roof Decks Offering Expansive Outdoor Spaces With Panoramic Views
- Performs 25% Better Than the 2015 Seattle Energy Code Requirements

Driven by rapid advances in medicine and technology, the life sciences market is going through a period of accelerated innovation — one that is having a significant impact on company culture and the physical workplace itself. Design solutions are far more bold than they used to be. Healthy, vibrant, and resilient spaces have become a priority because they help organizations stay agile, effective, and competitive in a fast-changing landscape.
222 Fifth is an R&D hub purpose-built for flexibility, tenant engagement, and long-term sustainability. Designed to meet the evolving needs of the life sciences industry, the building’s offset massing and dynamic volumes establish a striking identity. A bold feature stair drives vertical connectivity and movement, while terraces and a rooftop deck provide outdoor spaces with expansive views. Balancing work and research, 222 Fifth cultivates collaboration and continuously adapts to the shifting priorities of tenants and the surrounding community.
Sustainability is at the forefront of 222 Fifth’s design. The building performs 25% better than the 2015 Seattle Energy Code requirements, achieving enhanced energy efficiency through high-performance glazing and 100% electrified building systems including chilled beams and heat recovery HVAC. These sustainable features not only reduce environmental impact but also earned the building additional floor area through the Green Building Standard incentive program, ensuring long-term value for tenants and the surrounding community.












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International Design Awards announced its 2024 winners, including two Gold award-winning projects designed by Gensler — 222 Fifth, led by Principal Chad Yoshinobu, and Msheireb Downtown Doha, led by Principal Tariq Shaikh.
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Seattle Daily Journal of Commerce highlighted the Gensler-designed 222 Fifth, a state-of-the-art R&D building in Seattle that “serves as a gateway to the Uptown neighborhood.” The distinctive building features a curved glass facade, a striking red staircase, and unique offset massing.
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Archinect shared that Gensler is adding to Seattle’s growing innovation cluster with 222 Fifth, a medical and life sciences R&D building that prioritizes movement, flexibility, and the potential for new activations, which “set it apart from traditional research buildings.”
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The Registry featured 222 Fifth, a cutting-edge R&D building and modern workplace that adapts to the evolving needs of the industry and community. Architect Brian Di Maggio describes how Gensler’s design “features dynamic, shifting volumes that provide movement throughout the building.”

eleven50

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Design for Laboratory Resilience: A Compliance Approach to Climate Risk Assessment

Using an “All-Spokes” Approach to Optimize Lab Space

How Life Sciences Developments Can Redefine Urban Areas

The Benefits of Nurturing Organizational Pride in Life Science Workplaces

U.S. Laboratory Research Scientist Survey 2023

Resuscitating Buildings for Life Sciences and Healthcare
