222 Fifth

Seattle, Washington

A New Beacon of Innovation for Seattle

Located in the heart of Seattle’s innovation cluster, 222 Fifth is a state-of-the-art life science research facility and modern workplace that adapts to the evolving needs of the industry and surrounding community.

222 Fifth lobby with couches and plant wall

A woman sitting at round table in front of biophilic wall

A man sitting in lounge chair at 222 Fifth with view of monorail and museum

222 Fifth building rooftop with Space Needle and waterfront in the background

A couple taking a photo of 222 Fifth building exterior from inside monorail

Reflection of Space Needle on 222 Fifth facade

222 Fifth building with illuminated red staircase and Space Needle in the background

9-Stories, 200,000 Square Feet
100% Electric
Offset Massing and Dynamic Shifting Volumes
Interconnecting Stairs Act as a Vertical Ribbon of Circulation
Three Tenant-Ready Speculative Lab Floors
Multiple Roof Decks Offering Expansive Outdoor Spaces With Panoramic Views
Performs 25% Better Than the 2015 Seattle Energy Code Requirements

Driven by rapid advances in medicine and technology, the life sciences market is going through a period of accelerated innovation — one that is having a significant impact on company culture and the physical workplace itself. Design solutions are far more bold than they used to be. Healthy, vibrant, and resilient spaces have become a priority because they help organizations stay agile, effective, and competitive in a fast-changing landscape.

222 Fifth is an R&D hub purpose-built for flexibility, tenant engagement, and long-term sustainability. Designed to meet the evolving needs of the life sciences industry, the building’s offset massing and dynamic volumes establish a striking identity. A bold feature stair drives vertical connectivity and movement, while terraces and a rooftop deck provide outdoor spaces with expansive views. Balancing work and research, 222 Fifth cultivates collaboration and continuously adapts to the shifting priorities of tenants and the surrounding community.

Sustainability is at the forefront of 222 Fifth’s design. The building performs 25% better than the 2015 Seattle Energy Code requirements, achieving enhanced energy efficiency through high-performance glazing and 100% electrified building systems including chilled beams and heat recovery HVAC. These sustainable features not only reduce environmental impact but also earned the building additional floor area through the Green Building Standard incentive program, ensuring long-term value for tenants and the surrounding community.

222 Fifth sciences workplace and laboratory

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By combining world-class facilities with a prime location and forward-thinking initiatives like CoLabs, 222 Fifth is set to play a pivotal role in supporting Seattle’s growing life science ecosystem.

—Uly Rivera, Co-Labs Director with Lincoln Property Company

A man and woman walking up a red staircase.

A large building with a street in front of it.

A building with a city in the background.

Seattle city skyline and 222 Fifth rooftop in the evening

Aerial view of downtown Seattle in the evening — © Video and Images by Heywood Chan

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